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020 _a9783319041728
_9978-3-319-04172-8
024 7 _a10.1007/978-3-319-04172-8
_2doi
050 4 _aQ334-342
050 4 _aTA347.A78
072 7 _aUYQ
_2bicssc
072 7 _aCOM004000
_2bisacsh
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082 0 4 _a006.3
_223
100 1 _aChen, Qingfeng.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
245 1 0 _aIntelligent Strategies for Pathway Mining
_h[electronic resource] :
_bModel and Pattern Identification /
_cby Qingfeng Chen, Baoshan Chen, Chengqi Zhang.
250 _a1st ed. 2014.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2014.
300 _aXVIII, 299 p. 80 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aLecture Notes in Artificial Intelligence,
_x2945-9141 ;
_v8335
505 0 _aIntroduction -- Data Resources and Applications.- Detecting Inconsistency in Biological Molecular Databases Using Ontologies.- Exploration of Positive Frequent Patterns for AMP-Activated Protein Kinase Regulation.- Mining Protein Kinase Regulation Using Graphical Models -- Mining Inhibition Pathways for Protein Kinases on Skeletal Muscle.- Modeling Conserved Structure Patterns for Functional Noncoding RNA.- Interval Based Similarity for Function Classification of RNA Pseudoknots -- Discovery of Structural and Functional Features Bind to RNA Pseudoknots.- Mining Featured Patterns of MiRNA Interaction Based on Sequence and Structure Similarity -- Discovering Conserved and Diverged Patterns of MiRNA Families.- Bioinformatics-Based Drug Discovery for Protein Kinases.-  Conclusion and FutureWorks -- References.
520 _aThis book is organized into thirteen chapters that range over the relevant approaches and tools in data integration, modeling, analysis and knowledge discovery for signaling pathways. Having in mind that the book is also addressed for students, the contributors present the main results and techniques in an easily accessed and understood way together with many references and instances. Chapter 1 presents an introduction to signaling pathway, including motivations, background knowledge and relevant data mining techniques for pathway data analysis. Chapter 2 presents a variety of data sources and data analysis with respect to signaling pathway, including data integration and relevant data mining applications. Chapter 3 presents a framework to measure the inconsistency between heterogenous biological databases. A GO-based (genome ontology) strategy is proposed to associate different data sources. Chapter 4 presents identification of positive regulation of kinase pathways in terms of association rule mining. The results derived from this project could be used when predicting essential relationships and enable a comprehensive understanding of kinase pathway interaction. Chapter 5 presents graphical model-based methods to identify regulatory network of protein kinases. A framework using negative association rule mining is introduced in Chapter 6 to discover featured inhibitory regulation patterns and the relationships between involved regulation factors. It is necessary to not only detect the objects that exhibit a positive regulatory role in a kinase pathway but also to discover those objects that inhibit the regulation. Chapter 7 presents methods to model ncRNA secondary structure data in terms of stems, loops and marked labels, and illustrates how to find matched structure patterns for a given query. Chapter 8 shows an interval-based distance metric for computing the distance between conserved RNA secondary structures. Chapter 9 presents a framework to explore structural and functional patterns of RNA pseudoknot structure according to probability matrix. Chapter 10 presents methods to model miRNA data and identify miRNA interaction of cross-species and within-species. Chapter 11 presents an approach to measure the importance of miRNA site and the adjacent base by using information redundancy and develops a novel measure to identify strongly correlated infrequent itemsets. The discover association rules not only present important structural features in miRNAs, but also promote a comprehensive understanding of regulatory roles of miRNAs. Chapter 12 presents bioinformatics techniques for protein kinase data management and analysis, kinase pathways and drug targets, and describes their potential application in pharmaceutical industry. Chapter 13 presents a summary of the chapters and give a brief discussion to some emerging issues.
650 0 _aArtificial intelligence.
650 0 _aDatabase management.
650 0 _aAlgorithms.
650 0 _aApplication software.
650 0 _aInformation storage and retrieval systems.
650 0 _aComputer science.
650 1 4 _aArtificial Intelligence.
650 2 4 _aDatabase Management.
650 2 4 _aAlgorithms.
650 2 4 _aComputer and Information Systems Applications.
650 2 4 _aInformation Storage and Retrieval.
650 2 4 _aTheory of Computation.
700 1 _aChen, Baoshan.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
700 1 _aZhang, Chengqi.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783319041711
776 0 8 _iPrinted edition:
_z9783319041735
830 0 _aLecture Notes in Artificial Intelligence,
_x2945-9141 ;
_v8335
856 4 0 _uhttps://doi.org/10.1007/978-3-319-04172-8
912 _aZDB-2-SCS
912 _aZDB-2-SXCS
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